The Evangelical Presbyterian University College was established in 2008 by the Evangelical Presbyterian Church, Ghana. For a very long time now, the people of the Volta Region have been agitating for a university to be established in the region. Therefore when the door was opened by the government of Ghana to private organisations and individuals to establish universities, it became a challenge to the E.P. Church. At its 58th Synod held at Achimota School in Accra in the year 1999, the E.P. Church resolved to take the bold step of establishing a university in the Volta Region.